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Psilocybin Research

Psilocybin trials that are actually recruiting

Every open study, filterable by condition and location — and by the requirement that disqualifies more people than any other, which no registry puts in front of you.

The free routeReviewed

The short answer

133 psilocybin trials are currently open, 84 of them with sites in the United States, and joining one costs nothing. A trial is the only lawful route to supervised psilocybin in most of the country, and the sponsor covers the drug, the sessions and usually travel. The catch is eligibility: 43 of these studies require you to stop psychiatric medication to qualify, and a history of psychosis or bipolar I disorder excludes you from essentially all of them.

Open trials
133
With a US site
84
Require stopping medication
43
Cost to join
$0

Open studies

Find a trial

Search and filter, then contact the study team directly through their ClinicalTrials.gov entry. We do not screen anyone, refer anyone, or take a fee from any sponsor.

84 open trials.

  • Depression

    Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

    RecruitingPhase 3
    Registry terms
    Major Depression
    Where
    Alabama, Oregon, Pennsylvania, Washington · 5 sites
    Run by
    VA Office of Research and Development

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07226232Aiming to enroll 240

  • PTSD

    Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

    RecruitingPhase 2, Phase 3
    Registry terms
    PTSD - Post Traumatic Stress Disorder · PTSD · PTSD Symptoms
    Where
    New York
    Run by
    COMPASS Pathways

    Commonly excluded: Psychosis or bipolar history

    Full entry and contact details on ClinicalTrials.govNCT07570654Aiming to enroll 300

  • Cancer and end of life

    Psilocybin Therapy in Advanced Cancer

    RecruitingPhase 2, Phase 3
    Registry terms
    Advanced Cancer
    Where
    Colorado, New York · 2 sites
    Run by
    NYU Langone Health

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05398484Aiming to enroll 200

  • Depression

    The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

    RecruitingPhase 3
    Registry terms
    Major Depressive Disorder
    Where
    Massachusetts
    Run by
    Sharmin Ghaznavi

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06247839Aiming to enroll 20

  • PTSD

    Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD

    RecruitingPhase 2
    Registry terms
    Post Traumatic Stress Disorder · PTSD
    Where
    Maryland
    Run by
    Sunstone Medical

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06902974Aiming to enroll 70

  • Pain

    Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain

    Not yet recruitingPhase 2
    Registry terms
    Chronic Low Back Pain (CLBP) · Physical Therapy · Psilocybin
    Where
    Connecticut
    Run by
    Yale University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT07306364Aiming to enroll 45

  • Depression

    Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

    RecruitingPhase 2
    Registry terms
    Lung Non-Small Cell Carcinoma · Unipolar Depression
    Where
    Ohio
    Run by
    Alan Davis

    Commonly excluded: Recent suicidality

    Full entry and contact details on ClinicalTrials.govNCT07216404Aiming to enroll 10

  • Substance use

    5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

    RecruitingPhase 2
    Registry terms
    Tobacco Use Disorder
    Where
    Alabama, Maryland, New York · 3 sites
    Run by
    Johns Hopkins University
    Full entry and contact details on ClinicalTrials.govNCT05452772Aiming to enroll 66

  • PTSD

    State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

    RecruitingPhase 2
    Registry terms
    PTSD
    Where
    Texas
    Run by
    Baylor College of Medicine
    Full entry and contact details on ClinicalTrials.govNCT06888128Aiming to enroll 15

  • Depression

    Pragmatic Trial of Psilocybin Therapy in Palliative Care

    RecruitingPhase 2
    Registry terms
    Demoralization
    Where
    California, Maryland · 5 sites
    Run by
    Charles S. Grob, M.D.

    Commonly excluded: Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05403086Aiming to enroll 100

  • Anxiety

    Psilocybin for Treatment of OCD-2

    Not yet recruitingPhase 1, Phase 2
    Registry terms
    Obsessive - Compulsive Disorder
    Where
    Arizona
    Run by
    Francisco A Moreno

    Commonly excluded: Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06992999Aiming to enroll 20

  • Depression

    Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

    RecruitingPhase 2
    Registry terms
    Bipolar II Disorder · Depression, Bipolar · Suicidality
    Where
    Texas
    Run by
    The University of Texas Health Science Center, Houston

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality

    Full entry and contact details on ClinicalTrials.govNCT06706232Aiming to enroll 10

  • Depression · Substance use

    Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

    Not yet recruitingPhase 1, Phase 2
    Registry terms
    Treatment Resistant Depression · Substance Use Disorders
    Where
    Indiana · 2 sites
    Run by
    Indiana University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07499583Aiming to enroll 50

  • Other

    Mindfulness-Assisted Psychedelic Therapy

    RecruitingPhase 2
    Registry terms
    Mental Health
    Where
    California
    Run by
    University of Southern California

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06233344Aiming to enroll 40

  • Depression

    Group PACBT for Depression

    Not yet recruitingPhase 2
    Registry terms
    Depression - Major Depressive Disorder · Psilocybin · Cognitive Behavioral Therapy
    Where
    California
    Run by
    University of California, Los Angeles

    Commonly excluded: Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07566104Aiming to enroll 30

  • Depression

    Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder

    RecruitingPhase 2
    Registry terms
    Major Depressive Disorder
    Where
    New York
    Run by
    Icahn School of Medicine at Mount Sinai

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06592833Aiming to enroll 60

  • Healthy volunteers

    The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function

    Not yet recruitingPhase 1, Phase 2
    Registry terms
    Healthy
    Where
    Texas
    Run by
    Manoj Doss

    Commonly excluded: Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07079852Aiming to enroll 48

  • Depression · PTSD

    Mindfulness-based Psilocybin Therapy for PTSD

    RecruitingPhase 2
    Registry terms
    Post Traumatic Stress Disorder · Depression - Major Depressive Disorder
    Where
    Ohio
    Run by
    Anthony P King

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07104916Aiming to enroll 30

  • Depression

    Investigation to Understand and Optimize Psilocybin

    RecruitingPhase 2
    Registry terms
    Depression
    Where
    Colorado
    Run by
    Charles Raison

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT06512194Aiming to enroll 141

  • Substance use

    Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

    RecruitingPhase 2
    Registry terms
    Alcohol Use Disorder
    Where
    New York
    Run by
    NYU Langone Health

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06349083Aiming to enroll 200

  • Other

    NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy

    Not yet recruitingPhase 2
    Registry terms
    Psilocybin · Neuropathy
    Where
    Texas
    Run by
    M.D. Anderson Cancer Center

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07227909Aiming to enroll 83

  • Depression

    Psilocybin rTMS for Treatment Resistant Depression

    RecruitingPhase 2
    Registry terms
    Treatment Resistant Depression · MDD · Major Depressive Disorder
    Where
    Texas
    Run by
    University of Texas at Austin

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06132178Aiming to enroll 100

  • Substance use · Cancer and end of life · Pain

    Psilocybin in Cancer Pain Study

    RecruitingPhase 2
    Registry terms
    Opioid-Related Disorders · Pain Management · Pain Management and Care
    Where
    Massachusetts
    Run by
    Yvan Beaussant, MD, MSci

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06001749Aiming to enroll 15

  • Depression

    Psilocybin-Assisted Therapy as a Treatment for Depression

    Not yet recruitingPhase 2
    Registry terms
    Depression
    Where
    Missouri
    Run by
    Washington University School of Medicine

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07582120Aiming to enroll 50

  • Depression

    Psilocybin to Treat Depression in Spinal Cord Injury

    RecruitingPhase 1, Phase 2
    Registry terms
    Spinal Cord Injury · Depression - Major Depressive Disorder · Veteran
    Where
    New York
    Run by
    James J. Peters Veterans Affairs Medical Center

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07251491Aiming to enroll 30

  • PTSD

    Psilocybin-Assisted Therapy

    Not yet recruitingPhase 2
    Registry terms
    PTSD
    Where
    Georgia
    Run by
    Emory University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder

    Full entry and contact details on ClinicalTrials.govNCT07332143Aiming to enroll 150

  • Depression · Cancer and end of life · Anxiety

    TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

    RecruitingPhase 2
    Registry terms
    Depression · Anxiety · Cancer
    Where
    Texas
    Run by
    M.D. Anderson Cancer Center

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06801041Aiming to enroll 20

  • Neurological

    Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin

    Not yet recruitingPhase 2
    Registry terms
    Alzheimer's Disease
    Where
    Maryland
    Run by
    National Institute on Aging (NIA)

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT07721467Aiming to enroll 200

  • Depression · Anxiety

    Psilocybin-Assisted Therapy for Intergenerational Trauma

    RecruitingPhase 2
    Registry terms
    Psychological Stress · Depression · Anxiety
    Where
    New York
    Run by
    Rachel Yehuda

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06899165Aiming to enroll 100

  • Substance use

    Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder

    Not yet recruitingPhase 2
    Registry terms
    Alcohol Use Disorder
    Where
    Massachusetts
    Run by
    Brigham and Women's Hospital

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07296094Aiming to enroll 36

  • Substance use

    Wellcome Leap Psilocybin for OUD

    RecruitingPhase 2
    Registry terms
    Opioid Use Disorder
    Where
    Pennsylvania
    Run by
    Anna Rose Childress, Ph.D.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT06786325Aiming to enroll 36

  • Substance use

    Psilocybin for Opioid Use Disorder (OUD)

    RecruitingPhase 2
    Registry terms
    Opioid Use Disorder
    Where
    New Mexico, New York · 5 sites
    Run by
    NYU Langone Health

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT06796062Aiming to enroll 480

  • Healthy volunteers

    Psilocybin Efficacy With or Without Pimavanserin Pretreatment

    RecruitingPhase 1, Phase 2
    Registry terms
    Mood (Psychological Function) · Well Being · Mood
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder

    Full entry and contact details on ClinicalTrials.govNCT07610135Aiming to enroll 20

  • Substance use

    Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

    RecruitingPhase 2
    Registry terms
    Opioid Use Disorder
    Where
    Maryland
    Run by
    Johns Hopkins University

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Full entry and contact details on ClinicalTrials.govNCT06067737Aiming to enroll 90

  • Eating disorders

    Study of Psilocybin for Anorexia in Young Adults

    RecruitingPhase 2
    Registry terms
    Anorexia Nervosa
    Where
    California · 2 sites
    Run by
    Marissa Raymond-Flesch, MD, MPH

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06399263Aiming to enroll 40

  • Substance use

    Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial

    RecruitingPhase 2
    Registry terms
    Alcohol Use Disorder · Alcohol Dependence · Alcohol Abuse
    Where
    Iowa
    Run by
    University of Iowa

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06405607Aiming to enroll 80

  • Depression · Neurological

    Psilocybin Therapy for Depression in Parkinson's Disease

    RecruitingPhase 2
    Registry terms
    Parkinson Disease · Depression
    Where
    California
    Run by
    Joshua Woolley, MD, PhD
    Full entry and contact details on ClinicalTrials.govNCT06455293Aiming to enroll 60

  • Substance use

    Psilocybin on Brain Mechanisms of Motivation in OUD

    RecruitingPhase 2
    Registry terms
    Opioid Use Disorder
    Where
    Pennsylvania
    Run by
    University of Pennsylvania

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT06810310Aiming to enroll 24

  • Substance use

    Psilocybin Therapy for Methamphetamine Use Disorder and HIV

    Not yet recruitingPhase 2
    Registry terms
    Methamphetamine Use Disorder · Human Immunodeficiency Virus (HIV)
    Where
    California
    Run by
    Nicky Mehtani, MD, MPH

    Commonly excluded: Psychosis or bipolar history · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07756736Aiming to enroll 30

  • Other

    Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter

    Not yet recruitingPhase 2
    Registry terms
    Stuttering
    Where
    New York
    Run by
    NYU Langone Health

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07296328Aiming to enroll 25

  • Depression

    RCT of Psilocybin-assisted CBT for Depression

    RecruitingPhase 1, Phase 2
    Registry terms
    Major Depressive Diorder
    Where
    California
    Run by
    University of California, Los Angeles

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07281352Aiming to enroll 50

  • Depression

    Study of Psilocybin Under Anesthesia Controlled by EEG

    Not yet recruitingPhase 2
    Registry terms
    Major Depression
    Where
    California
    Run by
    Stanford University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07479550Aiming to enroll 10

  • Healthy volunteers

    Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

    RecruitingPhase 1, Phase 2
    Registry terms
    Healthy
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05301608Aiming to enroll 30

  • Depression · Cancer and end of life · Anxiety

    Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

    RecruitingPhase 2
    Registry terms
    Depression, Anxiety · Psilocybin-Assisted Psychotherapy · Advanced Cancer
    Where
    Texas
    Run by
    M.D. Anderson Cancer Center

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06200155Aiming to enroll 30

  • Other

    Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids

    Not yet recruitingPhase 2
    Registry terms
    Hematopoietic and Lymphatic System Neoplasm · Malignant Solid Neoplasm
    Where
    New York
    Run by
    Roswell Park Cancer Institute

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06827054Aiming to enroll 20

  • Substance use

    Psilocybin for Methamphetamine Use Disorder

    Not yet recruitingPhase 2
    Registry terms
    Methamphetamine Use Disorder
    Where
    Alabama
    Run by
    Peter Hendricks

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07774702Aiming to enroll 42

  • Depression · Neurological

    The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

    RecruitingPhase 2
    Registry terms
    Depression · Parkinson's Disease (PD)
    Where
    Connecticut
    Run by
    Yale University

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07610369Aiming to enroll 40

  • Other

    Psilocybin-Assisted Therapy for Physician Well-Being and Burnout

    RecruitingPhase 1, Phase 2
    Registry terms
    Burnout · Burnout, Healthcare Workers
    Where
    California
    Run by
    University of California, San Diego

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06814522Aiming to enroll 10

  • Healthy volunteers

    Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers

    RecruitingPhase 2
    Registry terms
    Healthy Participants With Lower-than-average Mental Well-being
    Where
    California
    Run by
    Robin Carhart-Harris, PhD, MA

    Commonly excluded: Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06626139Aiming to enroll 120

  • Other

    Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life

    Not yet recruitingPhase 1
    Registry terms
    Aging · Longevity · Biomarkers of Aging
    Where
    Colorado
    Run by
    Charles Raison

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Full entry and contact details on ClinicalTrials.govNCT07719088Aiming to enroll 50

  • Other

    The Effects of Psilocybin on Social Connectedness

    Not yet recruitingPhase 1
    Registry terms
    Loneliness · Grief
    Where
    Connecticut
    Run by
    Yale University

    Commonly excluded: Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07693153Aiming to enroll 51

  • Other

    Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain

    RecruitingPhase 1
    Registry terms
    Perception Disorders
    Where
    California
    Run by
    University of California, Berkeley

    Commonly excluded: Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05265546Aiming to enroll 80

  • Substance use

    Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

    RecruitingPhase 1
    Registry terms
    Opioid Use Disorder
    Where
    Connecticut
    Run by
    Yale University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Substance use disorder · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT06160284Aiming to enroll 12

  • Healthy volunteers

    Psilocybin Administration With 5-HT1a Blockade

    RecruitingEarly Phase 1
    Registry terms
    Psychedelic Effects in Healthy Volunteers
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07565493Aiming to enroll 18

  • PTSD

    Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

    RecruitingPhase 1
    Registry terms
    Posttraumatic Stress Disorder
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06989957Aiming to enroll 40

  • Pain

    Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study

    Not yet recruitingPhase 1
    Registry terms
    Chronic Pelvic Pain
    Where
    Oregon
    Run by
    Oregon Health and Science University

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06988319Aiming to enroll 15

  • Pain

    Psilocybin as a Treatment for Chronic Pain in Smokers

    RecruitingEarly Phase 1
    Registry terms
    Smokers With Chronic Pain
    Where
    Connecticut · 2 sites
    Run by
    Yale University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder

    Full entry and contact details on ClinicalTrials.govNCT07118332Aiming to enroll 10

  • Other

    Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

    RecruitingEarly Phase 1
    Registry terms
    Amyotrophic Lateral Sclerosis
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06656702Aiming to enroll 24

  • Pain

    Psilocybin After Trauma Surgery for Pain

    Not yet recruitingPhase 1
    Registry terms
    Pain Management · Postoperative Pain
    Where
    Pennsylvania
    Run by
    Trent Emerick

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07406828Aiming to enroll 70

  • Neurological

    Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

    RecruitingPhase 1
    Registry terms
    Stroke · Chronic Stroke · Intracerebral Haemorrhage
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07053917Aiming to enroll 20

  • Other

    Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study

    Not yet recruitingPhase 1
    Registry terms
    Well-Being, Psychological · Psychedelic Experiences
    Where
    Wisconsin
    Run by
    University of Wisconsin, Madison

    Commonly excluded: Recent suicidality

    Full entry and contact details on ClinicalTrials.govNCT07360301Aiming to enroll 120

  • Depression · PTSD · Substance use · Anxiety

    Open-Label Psilocybin Study in Transdiagnostic Population

    RecruitingPhase 1
    Registry terms
    Transdiagnostic · Depression - Major Depressive Disorder · Anxiety
    Where
    Connecticut
    Run by
    Yale University
    Full entry and contact details on ClinicalTrials.govNCT06442423Aiming to enroll 50

  • Substance use

    Psilocybin for Methamphetamine Addiction

    RecruitingEarly Phase 1
    Registry terms
    Methamphetamine Use Disorder
    Where
    Louisiana
    Run by
    Kevin Murnane

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06899594Aiming to enroll 20

  • Other

    Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)

    Not yet recruitingEarly Phase 1
    Registry terms
    IBS - Irritable Bowel Syndrome
    Where
    New York
    Run by
    NYU Langone Health

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06760533Aiming to enroll 10

  • Depression · Pain

    Psilocybin in Chronic Low Back Pain and Depression

    RecruitingPhase 1
    Registry terms
    Chronic Low-back Pain · Depression
    Where
    Maryland
    Run by
    Johns Hopkins University

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06355414Aiming to enroll 40

  • Other

    Psilocybin for Prolonged Grief Disorder

    RecruitingEarly Phase 1
    Registry terms
    Prolonged Grief Disorder
    Where
    Virginia
    Run by
    University of Virginia
    Full entry and contact details on ClinicalTrials.govNCT06724289Aiming to enroll 12

  • Healthy volunteers

    Safety and Tolerability Trial of Psilocybin in Healthy Older Adults

    RecruitingPhase 1
    Registry terms
    Healthy Volunteer · Older Adults (65-85 Years)
    Where
    California, Colorado, Georgia, Massachusetts, Nebraska, New York · 6 sites
    Run by
    University of Colorado, Denver

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder

    Full entry and contact details on ClinicalTrials.govNCT07516405Aiming to enroll 40

  • Other

    PRoMiSS: Psilocybin and the Role of Music in Set and Setting

    Enrolling by invitationPhase 1
    Registry terms
    Psilocybin · Music Intervention
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07180108Aiming to enroll 100

  • Other

    The RECAP2 Study: Midazolam and Psilocybin

    RecruitingPhase 1
    Registry terms
    Psilocybin
    Where
    Wisconsin
    Run by
    University of Wisconsin, Madison

    Commonly excluded: Recent suicidality

    Full entry and contact details on ClinicalTrials.govNCT06692192Aiming to enroll 60

  • Other

    Psilocybin as a Novel Therapy for Residual Anhedonia

    Not yet recruitingPhase 1
    Registry terms
    Anhedonia · Emotional Blunting
    Where
    New York
    Run by
    NYU Langone Health

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07607938Aiming to enroll 90

  • Cancer and end of life

    Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence

    RecruitingPhase 1
    Registry terms
    Breast Cancer · Ovarian Cancer
    Where
    Colorado · 2 sites
    Run by
    University of Colorado, Denver

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06430541Aiming to enroll 20

  • Healthy volunteers

    The ENHANCE Study: taVNS and Psilocybin

    RecruitingPhase 1
    Registry terms
    Healthy · Psychedelic Experiences · Vagus Nerve Stimulation
    Where
    Wisconsin
    Run by
    University of Wisconsin, Madison

    Commonly excluded: Psychosis or bipolar history · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05866471Aiming to enroll 108

  • Pain

    Psilocybin With Intracranial Neural Sensing

    Enrolling by invitationPhase 1
    Registry terms
    Chronic Pain
    Where
    California
    Run by
    Joshua Woolley, MD, PhD

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Full entry and contact details on ClinicalTrials.govNCT06919640Aiming to enroll 20

  • Healthy volunteers

    A Study of Psychedelics in Healthy Older Adults With Low Well-being

    RecruitingPhase 1
    Registry terms
    Anhedonia in Healthy Volunteers · Older Adults (50-90 Years)
    Where
    California
    Run by
    Jennifer Mitchell

    Commonly excluded: Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT07386730Aiming to enroll 80

  • Pain

    Psilocybin-facilitated Treatment for Chronic Pain

    RecruitingEarly Phase 1
    Registry terms
    Fibromyalgia, Primary
    Where
    Alabama
    Run by
    University of Alabama at Birmingham

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT05068791Aiming to enroll 30

  • Other

    Psilocybin-assisted Treatment for Cannabis Use Disorder

    RecruitingPhase 1
    Registry terms
    Cannabis Use Disorder
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06660381Aiming to enroll 12

  • Healthy volunteers

    Investigation of Psychedelic Effects in Psychoactive Substances

    RecruitingPhase 1
    Registry terms
    Psychedelic Effects in Healthy Volunteers
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06772753Aiming to enroll 50

  • Other

    Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

    RecruitingPhase 1
    Registry terms
    Aging
    Where
    California
    Run by
    University of California, Berkeley

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06367738Aiming to enroll 40

  • PTSD

    Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

    RecruitingPhase 1
    Registry terms
    PTSD
    Where
    New Mexico
    Run by
    University of New Mexico

    Requires stopping psychiatric medication. The eligibility criteria mention a taper or washout. Do not stop a prescription to qualify — ask the study team what is required and take it to your prescriber.

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07506395Aiming to enroll 36

  • Depression · Neurological

    Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

    RecruitingEarly Phase 1
    Registry terms
    Depressive Symptoms · Depression · Alzheimer Disease
    Where
    Maryland
    Run by
    Johns Hopkins University

    Commonly excluded: Psychosis or bipolar history · Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT04123314Aiming to enroll 20

  • Anxiety

    Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

    RecruitingPhase 1
    Registry terms
    Obsessive-Compulsive Disorder
    Where
    Arizona
    Run by
    Francisco A Moreno

    Commonly excluded: Psychosis or bipolar history · Family history of psychosis · Recent suicidality · Substance use disorder · Cardiovascular conditions · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07347405Aiming to enroll 30

  • Substance use

    Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine

    RecruitingPhase 1
    Registry terms
    Opioid Use Disorder
    Where
    Wisconsin
    Run by
    University of Wisconsin, Madison

    Commonly excluded: Cardiovascular conditions

    Full entry and contact details on ClinicalTrials.govNCT04161066Aiming to enroll 10

  • Pain

    Mechanistic Studies of Psilocybin in Headache Disorders

    RecruitingEarly Phase 1
    Registry terms
    Migraine
    Where
    Connecticut
    Run by
    Yale University

    Commonly excluded: Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT06464367Aiming to enroll 50

  • Other

    Psilocybin Microdosing on Cognition, Mood and Quality of Life

    Not yet recruitingEarly Phase 1
    Registry terms
    Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
    Where
    Connecticut
    Run by
    Yale University

    Commonly excluded: Psychosis or bipolar history · Recent suicidality · Substance use disorder · Pregnancy or breastfeeding

    Full entry and contact details on ClinicalTrials.govNCT07449351Aiming to enroll 20

How this list is built, and what it is not

These entries come from ClinicalTrials.gov, filtered to studies where psilocybin is an actual intervention rather than a passing mention, and to studies that are recruiting, about to recruit, or enrolling by invitation. Completed trials are excluded. They are research news — you can read about them on our evidence pages — but you cannot join one, and listing them is how other trial finders end up sending people to studies that closed years ago.

The registry is the authority, not us. Every entry links to its ClinicalTrials.gov record, and where our summary and that record disagree, the record governs. Trials close, pause and change criteria without notice, and this snapshot was taken on 2026-08-31.

We are not a recruiter. We have no relationship with any sponsor, we are not paid per inquiry or per enrollment, and we do not pass your details to anyone. If a site offers to “match” you to a psychedelic trial and asks for your contact details first, that is a lead-generation business, and you are the product being sold.

The eligibility criterion nobody surfaces

Of the 133 open trials here, 43 — a little under a third — have eligibility text mentioning a taper or washout of psychiatric medication. Given that roughly one in eight American adults takes an antidepressant, this quietly disqualifies an enormous share of the people who go looking for a trial in the first place.

We flag it on each card because every registry, and every commercial trial-finder we have looked at, buries it in a wall of inclusion and exclusion criteria that a non-specializt will not read to the end of. Surfacing it is most of the reason this page exists. Our flagging is keyword-based and deliberately errs toward showing the warning, so treat it as a prompt to ask rather than a verdict — the study team will tell you exactly what is required.

What screening actually involves

Contacting a study is not the same as joining one, and most people who inquire are found ineligible. Expect a phone screen, then a structured psychiatric interview, medical history, physical examination and often bloodwork. A personal or family history of psychosis or bipolar I disorder will exclude you from essentially every psilocybin trial, and that exclusion exists for a good reason rather than an administrative one.

If you are found eligible, read the informed consent document properly before signing it. Two questions worth asking that people forget: what happens if the experience goes badly during the session, and what follow-up you get after the study ends.

A participant wearing eyeshades lies on a couch under a blue blanket in a plainly furnished room while two session monitors sit beside them.

A psilocybin session room at Johns Hopkins, 2008. Six to eight hours on a couch in eyeshades with two monitors present — this, not a clinic brochure, is the setting almost every result on this site was produced in.

Matthew W. Johnson · CC BY-SA 3.0

What the evidence showsThe paid alternativesSafety and contraindications

Common questions

Questions about joining a trial

How do I join a psilocybin clinical trial?
Find a study whose condition and location fit, open its ClinicalTrials.gov entry, and contact the study team listed there directly. They screen you — no third party can enroll you, and nobody should charge you a fee to be referred. Screening usually involves a structured psychiatric interview, a medical history and often bloodwork, and most people who inquire are not eligible.
Do psilocybin trials pay participants?
Many compensate for time and travel, and the study drug and sessions are provided at no cost. Compensation varies widely and is listed by the individual study, not centrally. A trial should never cost you money to join; if you are asked to pay to participate, it is not a clinical trial.
Do I have to stop my antidepressant to join a psilocybin trial?
Often, yes. Of the 133 open psilocybin trials we track, 43 have eligibility criteria mentioning a taper or medication washout. This is the single most common reason people are excluded. Do not stop a prescription in order to qualify for anything — ask the study team exactly what is required and take that answer to the prescriber who knows your history. Discontinuation carries real relapse risk.
Are psilocybin clinical trials free?
Yes. In a properly conducted trial the sponsor covers the study drug, the dosing sessions and the study visits, and often travel. That makes trial participation the only lawful route to supervised psilocybin in most US states, and the cheapest by a wide margin — a licensed session in Oregon or Colorado costs $1,000 to $3,500 out of pocket.
What usually disqualifies people from psilocybin trials?
A personal or family history of psychosis or bipolar I disorder is an exclusion in essentially every psilocybin trial. Others that recur are recent suicidality, uncontrolled cardiovascular conditions, pregnancy or breastfeeding, current substance use disorder, and taking medication the study requires you to stop. Age ranges and the specific diagnosis being studied narrow it further.
Is it safe to join a psilocybin clinical trial?
Trials are the most closely supervised setting in which psilocybin is administered anywhere: screening, a trained monitor present throughout the session, and follow-up. That is a meaningful safety advantage over any unsupervised use. It is not zero risk, and the screening exists because the risks are real for specific groups. Read the informed consent document carefully and ask what happens if the experience goes badly.

References

  1. 1.Lewis G, et al. Maintenance or Discontinuation of Antidepressants in Primary Care (ANTLER). N Engl J Med. 2021;385:1257–67.56% relapsed within a year after discontinuation vs 39% on maintenance. The reason no website should tell you to stop your medication.
  2. 2.Erritzoe D, et al. Effect of recent SSRI discontinuation on psilocybin outcomes. J Psychopharmacol. 2024;38(5).Post-hoc: psilocybin's advantage over escitalopram held in never-medicated participants but disappeared among recent discontinuers. Inverts the common advice to taper quickly before a session.
  3. 3.ClinicalTrials.gov, US National Library of Medicine. Snapshot taken 2026-08-31.

This is not medical advice. We summarize public registry data so it is easier to search. Whether a trial is appropriate for you is a question for a clinician who knows your history and for the study team who will screen you.